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GastroPlus® is a mechanistically based simulation software package that simulates intravenous, oral, oral cavity, ocular, inhalation, dermal/ subcutaneous, and intramuscular absorption, pharmacokinetics, and pharmacodynamics in humans and animals. This smoothly integrated platform combines a user-friendly interface with powerful science to help you make faster and more informed project decisions!
Modeling and simulation package – supporting internal research through regulatory filings.
GastroPlus has been separated into modules to make it easier for companies to license only the features they need in each department.
As a researcher in the life sciences space, you can’t measure everything as a project winds its way through the R&D process. With the data that is being generated, you’re expected to make informed decisions as quickly as possible. A wrong one sets you back severely, both in terms of time, money, and getting to market. Now, more than ever, it is important to consider incorporating new technology across your company – like PBPK & PBBM modeling.
GastroPlus is a mechanistically based simulation software package that simulates intravenous, oral, oral cavity, ocular, inhalation, dermal, subcutaneous, and intramuscular absorption, biopharmaceutics, pharmacokinetics, and pharmacodynamics in humans and animals. This smoothly integrated platform combines a user-friendly interface with powerful science to help you make faster and more informed project decisions! GastroPlus has been separated into modules to make it easier for companies to license only the features they need in each department.
The PBPKPlus™ Module extends GastroPlus™ to define a physiologically based pharmacokinetic (PBPK) model consisting of various tissues. You can easily simulate the distribution and elimination of compound throughout the body and track concentrations in any tissue. Any tissue can employ fixed intrinsic clearance and with the Metabolism and Transporter Module, saturable (Michaelis-Menten) metabolism and transport (influx and efflux) can be incorporated. Tissues can be defined as needed, or default models can be used with a standard set of compartments:
Customize your PBPK model by treating any tissue as either a perfusion-limited or permeability-limited model, and quickly add/delete tissues as needed – all without writing any equations using the GastroPlus PBPK software!
NEW! Transporter-based IVIVE: automated scaling of permeability across tissues using a single parameter! Check out the Resource Center for more details on the approach and how it can be applied to scale across species or populations!
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Operating System: Windows
Application Category: Chemical & Materials
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