ZMT Sim4Life 2025 v9.0

ZMT Sim4Life is a comprehensive multiphysics simulation platform specifically designed for computational life sciences. It integrates electromagnetic, thermal, acoustic, and particle transport solvers with detailed anatomical models to simulate interactions between medical devices and biological tissues. The platform enables virtual prototyping, safety assessment, and efficacy evaluation of medical technologies, significantly reducing the need for animal testing and accelerating regulatory approval.

Primary Users

Sim4Life serves specialized professionals in biomedical computation:

• Medical Device Engineers developing MRIs, pacemakers, cochlear implants, and neuromodulation devices

• Pharmaceutical Researchers studying drug delivery and bio-distribution

• Computational Neuroscientists modeling brain stimulation and neural networks

• Regulatory Affairs Specialists preparing FDA/CE/MDR submissions with computational evidence

• Academic Researchers in biomedical engineering and biophysics

• Radiation Safety Officers assessing EM exposure and thermal effects

Key Features & Capabilities

Core Physics Solvers

• Electromagnetic Solver: Full-wave FDTD and FEM for RF, microwave, and low-frequency applications

• Thermal Solver: Pennes bioheat and detailed thermoregulation models

• Acoustic Solver: Ultrasound and photoacoustic simulation

• Particle Transport: Monte Carlo for ionizing radiation and light propagation

• Multiphysics Coupling: Electro-thermal, acoustic-thermal, and EM-acoustic interactions

Anatomical & Physiological Models

• Virtual Population (ViP): 50+ anatomically correct human models across ages, BMI, and postures

• Tissue Properties Database: 200+ tissues with frequency-dependent dielectric and thermal properties

• Physiological Models: Dynamic circulatory, respiratory, and neural system models

• Pathological Models: Tumors, edema, and other disease states

Medical Device Applications

• MRI Safety: RF heating and gradient-induced nerve stimulation

• Neuromodulation: DBS, TMS, tDCS, and spinal cord stimulation

• Wireless Power Transfer: Implant charging and body area networks

• Therapeutic Ultrasound: HIFU and lithotripsy planning

• Optical Technologies: Photodynamic therapy and pulse oximetry

What’s New in v9.0

Advanced Simulation Capabilities

1. AI-Powered Model Reduction: Machine learning creates reduced-order models from full simulations, enabling real-time parameter studies (1000x speedup)

2. Digital Twin of Patients: Integration with clinical imaging (MRI, CT) to create patient-specific models for personalized treatment planning

3. Quantum Biology Extension: Preliminary tools for simulating quantum effects in biological systems (photoactivation, magnetoreception)

4. Organ-on-Chip Simulation: Microfluidic and tissue engineering platform integration

Regulatory & Clinical Tools

5. MDR/IVDR Compliance Suite: Automated generation of technical documentation for EU medical device regulations

6. FDA ASF (Assurances of Safety & Effectiveness): Pre-configured templates for FDA computational modeling submissions

7. Clinical Trial Augmentation: Tools to supplement clinical trials with virtual cohorts

8. Real-World Evidence Integration: Import and analysis of post-market surveillance data

🖥️ System Requirements

Windows (Primary Platform)

Minimum Requirements:

• OS: Windows 10 Pro/Enterprise 64-bit (22H2) or Windows 11 Pro

• CPU: Intel Core i9-12900K or AMD Ryzen 9 7900X (16 cores)

• RAM: 64 GB (128 GB recommended for full-body models)

• GPU: NVIDIA RTX A5000 or RTX 4090 (24 GB VRAM minimum)

• Storage: 500 GB NVMe SSD + 2 TB for anatomical databases

• Display: 3840×2160 (4K) recommended for visualization

Recommended Configuration:

• • OS: Windows 11 Pro for Workstations

  • CPU: Intel Xeon w9-3495X or AMD Threadripper PRO 7995WX (96 cores)

  • RAM: 256 GB – 1 TB (for population studies)

  • GPU: NVIDIA RTX 6000 Ada (48 GB VRAM) or dual A6000

  • Storage: 2 TB NVMe Gen4 + 10 TB RAID for simulation data